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Urinary Inhibitors of the Formation of Calcium Oxalate
Author(s) -
SUTOR D. JUNE,
PERCIVAL JOSEPHINE M.,
DOONAN S.
Publication year - 1979
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1979.tb04703.x
Subject(s) - chemistry , pyrophosphate , oxalate , urea , calcium oxalate , urine , citric acid , calcium , chromatography , magnesium , sodium , potassium , ultrafiltration (renal) , inorganic chemistry , nuclear chemistry , biochemistry , enzyme , organic chemistry
Summary— Normal urine was examined for substances which inhibited the formation of calcium oxalate, using a separation scheme which involved ultrafiltration, alcohol precipitation, electrophoresis and paper chromatography. The major anionic inhibitors were found to be citric acid, isocitric acid and pyrophosphate. The inhibitory activity of urine and that of an artificial urine having the same concentration of urea, creatinine, sodium, potassium, magnesium, calcium, ammonia, sulphate, chloride, inorganic phosphate, oxalate, citrate, isocitrate and pyrophosphate, and the same pH were identical. This confirmed that urine does not contain an unidentified potent substance which inhibits the formation of calcium oxalate.