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Characterization of feline hereditary retinal dystrophies using clinical, functional, structural and molecular genetic studies
Author(s) -
Narfström Kristina,
Menotti Raymond Marilyn,
Seeliger Mathias
Publication year - 2011
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/j.1463-5224.2011.00915.x
Subject(s) - cats , retinal , biology , genetics , computational biology , medicine , biochemistry
Only in recent years have specific mutations been elucidated for feline hereditary retinal dystrophies. Molecular genetic characterization of feline diseases has so far been a slow process but with a full genome sequence for the cat recently completed and the development of a feline single nucleotide polymorphism chip, the characterization of feline monogenic disorders will be significantly simplified. This review summarizes current knowledge with regard to specific hereditary retinal dystrophies in cats and gives an overview of how cats can be used as models in translational research.