Premium
Advancements in ocular drug delivery
Author(s) -
Weiner Alan L.,
Gilger Brian C.
Publication year - 2010
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/j.1463-5224.2010.00835.x
Subject(s) - drug delivery , medicine , drug , patient compliance , biomedical engineering , nanotechnology , pharmacology , materials science , emergency medicine
This review covers both noninvasive and invasive ophthalmic drug delivery systems that can have application to therapy of veterinary ophthalmic diseases. Noninvasive approaches include gel technologies, permeation enhancement via pro‐drug development, solubilization agents and nanoparticle technologies, iontophoresis, microneedles, drug‐eluting contact lenses and eye misters, and microdroplets. More invasive systems include both eroding implants and noneroding technologies that encompass diffusion based systems, active pumps, intraocular lenses, suprachoroidal drug delivery, and episcleral reservoirs. In addition to addressing the physiologic challenges of achieving the necessary duration of delivery, tissue targeting and patient compliance, the commercial development factors of biocompatibility, sterilization, manufacturability and long‐term stability will be discussed.