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Anti‐diabetic effect of blockade of the renin‐angiotensin system
Author(s) -
Ando Katsuyuki,
Fujita Toshiro
Publication year - 2006
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2005.00526.x
Subject(s) - renin–angiotensin system , blockade , medicine , pharmacology , chemistry , receptor , blood pressure
Diabetes, which is frequently associated with hypertension, accelerates the development of hypertension‐induced cardiovascular disease. Thus, the prevention of diabetes is important in the management of hypertension. Recent clinical megastudies have suggested that the blockade of the renin‐angiotensin system (RAS) by angiotensin‐converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) inhibits new onset of diabetes. Thus, the agents to inhibit the RAS should be beneficial for glucose metabolism. However, the cardiovascular protective effects of ACE inhibitors and ARBs are not always superior to other classes of drugs. Further long‐term clinical trials are necessary to clarify the anti‐diabetic effect of the RAS‐inhibiting agents.