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Mice lacking 5‐HT 7 receptors show specific impairments in contextual learning
Author(s) -
Roberts Amanda J.,
Krucker Thomas,
Levy Coree L.,
Slanina Kristen A.,
Sutcliffe J. Gregor,
Hedlund Peter B.
Publication year - 2004
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2004.03288.x
Subject(s) - neuroscience , knockout mouse , 5 ht receptor , hippocampus , receptor , hippocampal formation , psychology , serotonin , long term depression , fear conditioning , synaptic plasticity , biology , glutamate receptor , ampa receptor , amygdala , biochemistry
Using 5‐HT 7 receptor knockout mice it has been shown that the 5‐HT 7 receptor is the main mediator of serotonin‐induced hypothermia but very little is known about the relevance of 5‐HT 7 receptors in behaviour. We here report that lack of 5‐HT 7 receptors leads to a specific learning deficit that is not due to general sensory or behavioural deficits. The knockout mice show impaired contextual fear conditioning but no significant deficits in motor and spatial learning or cued and operant conditioning. In addition, we demonstrate that 5‐HT 7 receptor knockout mice display decreased long‐term synaptic plasticity within the CA1 region of the hippocampus. The results indicate an important role for the 5‐HT 7 receptor in contextual hippocampal‐dependent learning and suggest a possible neuronal correlate for such a role is present within the CA1 region of the hippocampus.