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Reduced Synchronization in the Visual Cortex of Cats with Strabismic Amblyopia
Author(s) -
Roelfsema Pieter R.,
König Peter,
Engel Andreas K.,
Sireteanu Ruxandra,
Singer Wolf
Publication year - 1994
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1994.tb00556.x
Subject(s) - visual cortex , neuroscience , cortical neurons , cats , synchronization (alternating current) , cortex (anatomy) , population , neurophysiology , grating , spatial frequency , psychology , optics , physics , medicine , computer science , channel (broadcasting) , computer network , environmental health
Abstract Synchronous firing of spatially separate neurons was studied with multi‐electrode recordings in area 17 of the visual cortex of strabismic cats which had developed behaviourally verified amblyopia of the deviated eye. Responses of neurons were evoked with moving light bars or gratings of different spatial frequency. Neurons driven by the normal eye displayed stronger synchronization of their responses than neurons dominated by the amblyopic eye. These interocular differences were highly significant and particularly pronounced for grating stimuli of high spatial frequency. No interocular differences were noted with respect to the amplitudes of responses to the light bars and gratings. These results suggest reduced synchronization of population responses as a neurophysiological correlate of strabismic amblyopia and underline the importance of correlated firing of spatially separate cortical neurons for normal processing of visual information.