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Homocysteate, an Excitatory Transmitter Candidate Localized in Glia
Author(s) -
Grandes Pedro,
Do Kim Quang,
Morino Patrizia,
Cuénod Michel,
Streit Peter
Publication year - 1991
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1991.tb00070.x
Subject(s) - excitatory postsynaptic potential , neurotransmitter , neuroscience , glutamate receptor , immunocytochemistry , cerebellum , cerebellar cortex , biology , chemistry , microbiology and biotechnology , central nervous system , biochemistry , inhibitory postsynaptic potential , endocrinology , receptor
l ‐Homocysteate, a sulphur‐containing l ‐glutamate analogue has recently been proposed as a neurotransmitter candidate. However, the cellular localization of this excitatory amino acid remained to be determined. By means of immunocytochemistry, the localization of homocysteate was accomplished in the cerebellar cortex of rats. Cerebellar glia could be defined as the major store of this compound. Homocysteate, thus, may not be a classical neurotransmitter but rather a member of another class of intercellular messengers that might be termed ‘gliotransmitters’.
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