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The Relationship between the Level of Expression of Intercellular Adhesion Molecule‐1 in Placenta and Onset of Preeclampsia
Author(s) -
Oyama Rie
Publication year - 2001
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2001.tb01239.x
Subject(s) - preeclampsia , medicine , placenta , umbilical cord , umbilical artery , umbilical vein , gestation , andrology , icam 1 , intercellular adhesion molecule 1 , immunohistochemistry , pregnancy , gestational age , fetus , obstetrics , cell adhesion molecule , immunology , biology , in vitro , biochemistry , inflammation , genetics
Abstract Objective: To investigate the differences in the expression of intercellular adhesion molecule‐1 (ICAM‐1) in the placenta and the concentration of soluble ICAM‐1 between early‐onset and late‐onset preeclampsia. Methods: Preeclampsia was divided into early‐onset type (EO: 20 to 31 weeks gestation) and late‐onset type (LO: ≧ 32 weeks gestation). Post delivery, placentas were obtained from 19 control pregnant women and from 9 EO and 8 LO preeclamptic women. The expression of ICAM‐1 in placenta was determined by immunohistochemical staining. Blood samples were taken from 21 non‐pregnant women, 16 control pregnant women, 13 EO and 8 LO preeclamptic women, and umbilical cord blood samples from 38 control pregnancies and from 16 EO and 14 LO preeclampsia. The concentration of ICAM‐1 was measured by enzyme‐linked immunosorbent assays. Results: The expression of ICAM‐1 in placenta was higher in LO than in EO preeclampsia (48.2 + 8.2% vs 17.9 + 5.0%) (p < 0.05). ICAM‐1 concentration in umbilical cord blood was higher in EO than in LO preeclampsia (umbilical artery, 150.6 + 34.0 ng/ml vs 90.3 + 9.4 ng/ml) (umbilical vein, 128.3 + 31.2 ng/ml vs 91.3 + 10.2 ng/ml) (p < 0.05). Conclusions: Significant differences were noted in the expression of ICAM‐1 between patients with EO and LO preeclampsia, which suggest that the possibility that EO and LO preeclampsia may have different onset mechanisms.