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Status of Transferrin Receptors in Benign and Malignant Lesions of the Cervix
Author(s) -
Buckshee K.,
Saha D A.,
Agarwal N.,
Singh G.
Publication year - 1987
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1987.tb00295.x
Subject(s) - transferrin , immunostaining , receptor , pathology , transferrin receptor , reactivity (psychology) , medicine , cervix , significant difference , immunohistochemistry , cancer , alternative medicine
Abstract Reactivity for transferrin receptors was studied in 9 cases with benign and 11 cases with malignant lesions of the cervix. Immunostaining reaction for transferrin receptors was positive in 9/11 (81.8%) of the malignant lesions. However, the reactivity was absent (0%) in all of the 9 specimens with benign lesions. The difference in reactivity pattern between benign and malignant lesions was highly remarkable (P< 0.001 Fischer's exact test). Thus the present study denotes that transferrin receptors are associated with active cellular growth (malignant lesions) and virtually absent in the resting tissues (benign lesions).