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Case of anti‐glomerular basement membrane antibody‐induced glomerulonephritis with cytomegalovirus‐induced thrombotic microangiopathy
Author(s) -
Shiraishi N.,
Kitamura K.,
Hayata M.,
Ogata T.,
Adachi M.,
Kajiwara K.,
Ikeda H.,
Miyoshi T.,
Tomita K.
Publication year - 2012
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2011.02703.x
Subject(s) - thrombotic microangiopathy , medicine , cytomegalovirus , ganciclovir , microangiopathy , immunology , glomerulonephritis , antibody , virology , human immunodeficiency virus (hiv) , herpesviridae , viral disease , virus , human cytomegalovirus , kidney , endocrinology , disease , diabetes mellitus
Although the involvement of cytomegalovirus (CMV) infections in the development of thrombotic microangiopathy (TMA) in HIV patients and transplant recipients has been reported, it is still controversial whether CMV itself can cause TMA. We report herein a rare case with rapid improvement of TMA by ganciclovir treatment in a patient who is neither HIV‐positive nor a transplant recipient, suggesting a pathogenic role for CMV in TMA.