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A COMPARISON OF INTRAVENOUS AND INTRACORONARY STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION
Author(s) -
WOOLLARD K. V.,
MEWS G. C.,
COPE G. D.,
CUMPSTON N.,
IRELAND M. A.,
DAVIS M. J. E.,
BLACK A. J.,
TAYLOR R. R.
Publication year - 1984
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1984.tb03619.x
Subject(s) - medicine , streptokinase , myocardial infarction , intravenous therapy , artery , cardiology , intravenous use , anesthesia
Abstract: A randomised study of intravenous and intracoronary streptokinase therapy was carried out in 20 subjects with acute myocardial infarction and angiographically confirmed complete obstruction of the associated coronary artery. Two dose levels of therapy were used. Although more recanalisations occurred with intracoronary than intravenous therapy at the low dose levels, overall there was not a significant difference between the two groups; one million IU intravenously over 20 minutes recanalised four of five arteries. While seven of nine recanalisations with intracoronary therapy occurred within an hour, only two of five with intravenous therapy did so. Hence prolonged angiographic observation is necessary to document recanalisation with intravenous therapy adequately. Nevertheless, the time disadvantage of large dose intravenous therapy is not great and it may yet prove as effective as, and more practical than, intracoronary therapy.