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VEIN TO ARTERY GRAFTS: A STUDY OF RE‐INNERVATION IN RELATION TO NEO‐INTIMAL HYPERPLASIA
Author(s) -
Meagher Stephen,
Mcgeachie JohnK.,
Prendergast FrancisJ.
Publication year - 1987
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1987.tb01447.x
Subject(s) - medicine , intimal hyperplasia , vein , artery , hyperplasia , cardiology , surgery , smooth muscle
This study was undertaken to determine whether there is an association between the sympathetic re‐innervartion and development of neo‐intimal smooth muscle hypetplasia in vein to artery grafts. Iliolumbar vein to iliac artery grafts were placed in 21 rats by microsargical techniques. Graft innervation and neo‐intimal thickness were examined at five time intervals between 1 and 32 weeks after grafting. Nerve fibres were demonstrated microscopically by formaldehyde‐induced fluorescence of catecholamines. The degree of innervation was quantitated by counting the nerve profiles and this was compared with the amount of neo‐imimal hyperplasia. The distance between adventitial nerve profiles and neo‐intima (‘diffusion’ distance) was measured to determine whether there was a trophic interaction between the two. These data were compared with similar measurements in control iliac arteries in the same animals. Although the development of both graft innervation and neo‐intimal hyperplasia occurred coincidemally, no definite quantitative association between the two was established.