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NEONATAL NECROTIZING ENTEROCOLITIS: A CAUSE OF GASTRIC METAPALASIA IN THE MID‐ILEUM
Author(s) -
Ford W. D. Andrew,
Phillips Gael E.,
Davidson Geoffrey P.,
Douglas Brian
Publication year - 1986
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1986.tb02351.x
Subject(s) - necrotizing enterocolitis , medicine , ileum , laparotomy , immunoperoxidase , gastroenterology , enterocolitis , gastric mucosa , pathology , biopsy , stomach , surgery , antibody , immunology , monoclonal antibody
Following neonatal necrotizing enterocolitis in a premature Aboriginal baby, a stricture developed in the distal small intestine. At laparotomy a 1.0 cm stricture was found in a 25 cm thick‐walled, oedematous segment of the mid‐ileum. Biopsy demonstrated antropyloric‐type ectopic mucosa and, therefore, the oedematous segment was removed. The resected specimen contained several distinct areas of flat antropyloric gastric mucosa as well as ileal mucosa. Although no acid‐producing cells could be demonstrated, mucosal ulceration was prominent in several areas. Scanning electron microscopy demonstrated gastric pits. Immunoperoxidase technique for gastrin failed to demonstrate gastrin‐containing cells. It is believed that this mucosa represents a metaplasia that has been induced in response to mucosal damage, which in turn was initiated by necrotizing enterocolitis. It is believed this would represent the first reported case.