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The Effect of Irradiated Cells on Tumour Growth 1
Author(s) -
Bray A. E.
Publication year - 1974
Publication title -
australian and new zealand journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 51
eISSN - 1445-2197
pISSN - 0004-8682
DOI - 10.1111/j.1445-2197.1974.tb03920.x
Subject(s) - medicine , irradiation , stimulation , melanoma , immune system , cancer research , cell , cell growth , microbiology and biotechnology , immunology , biology , biochemistry , physics , nuclear physics
The effect on tumour growth of adding heavily irradiated cells to a standard number of viable mouse melanoma tumour cells before its inoculation into the syngeneic host was investigated. It was found that admixed irradiated syngeneic tumour cells stimulated tumour growth. Irradiated syngeneic fibroblasts had no effect. Irradiated tumour cells with a strong histocompatability difference inhibited tumour growth. It is possible that this inhibitory effect was due to a stimulation of the host immune system.