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PRIMARY GASTRIC PLASMACYTOMA REFRACTORY TO HELICOBACTER PYLORI ERADICATION THERAPY
Author(s) -
Kawasaki Naruo,
Nakada Koji,
Kawasaki Yuko,
Suzuki Yutaka,
Masuda Katsunori,
Miyazawa Yoshio,
Kashiwagi Hideyuki,
Yanaga Katsuhiko
Publication year - 2009
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.2008.00816.x
Subject(s) - medicine , curvatures of the stomach , helicobacter pylori , plasmacytoma , biopsy , gastrectomy , stomach , splenectomy , gastroenterology , lymph node , argon plasma coagulation , endoscopy , surgery , pathology , cancer , spleen , multiple myeloma
A 49‐year‐old woman underwent upper gastrointestinal endoscopic examination for epigastric discomfort, revealing giant folds on the greater curvature of the stomach. Histological examinations of biopsy specimens taken from the giant folds showed signs of chronic inflammation, and Helicobacter pylori was also identified. She underwent first‐step H. pylori eradication. On follow‐up endoscopy, H. pylori was not identified. However, endoscopic findings were unchanged and repeated biopsies showed dense infiltration of atypical plasma cells. No proliferation of centrocyte‐like cells was seen. Immunohistochemically, plasma cells were positive for λ‐chain. Primary gastric plasmacytoma was diagnosed. Total gastrectomy was carried out with splenectomy and regional lymph node dissection. The patient remains disease free as of 6 years postoperatively.