Premium
Thrombotic thrombocytopenic purpura in advanced prostate cancer: Case report and published work review
Author(s) -
Caramello Valeria,
Dovio Andrea,
Caraci Pasquale,
Berruti Alfredo,
Angeli Alberto
Publication year - 2007
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01644.x
Subject(s) - medicine , thrombotic thrombocytopenic purpura , microangiopathic hemolytic anemia , thrombocytopenic purpura , prostate cancer , schistocyte , cancer , hemolytic anemia , platelet , coagulation disorder , refractory (planetary science) , coagulation , gastroenterology , dermatology , physics , astrobiology
Thrombotic thrombocytopenic purpura (TTP) is a generalized disorder of the microcirculation characterized by microangiopathic hemolytic anemia (MHA), thrombocytopenic purpura and systemic microvascular thrombi. TTP has been previously described in two patients with prostate cancer (PC). We report a third case of TTP in a 61‐year‐old man with hormone‐refractory bone metastatic PC. The syndrome presented with confusion, anuric acute renal failure, thrombocytopenia and MHA. A satisfactory recovery was achieved after plasma exchange (PE). TTP should be included in the coagulation disorders occurring in PC patients. Early treatment with plasma exchange is recommended in these particular cases.