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Nonfunctioning Adrenal Cortical Cancer and Analysis of the Steroidogenic Activity of the Tumor: A Case Report
Author(s) -
Morioka Masaaki,
Tanaka Hiroyoshi,
Ohashi Yozo,
Jin TieXiong,
Watanabe Hironobu,
Furihata Mutsuo
Publication year - 1998
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1998.tb00270.x
Subject(s) - medicine , magnetic resonance imaging , pathology , pleomorphism (cytology) , radiology , immunohistochemistry
An adrenocortical cancer was detected by a CT scan in a 37‐year‐old woman, which did not have an excessive secretion of steroids or catecholamines. The tumor was enhanced inhomogeneously by the bolus injection of contrast medium, and magnetic resonance imaging (MRI) showed that the tumor was hypointense compared to the liver on a T1‐weighted image and was diffusely hyperintense on a T2‐weighted image. Histologically, the tumor consisted predominantly of compact cells with marked cellular and nuclear pleomorphism, but no capsular or vascular invasion were observed. An analysis of the steroidogenic activity of the tumor revealed that the activity of mitochondrial P450c11j8 was extremely reduced in the tumor.