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Pulmonary presentations of amyloidosis
Author(s) -
Howard Mark E.,
Ireton John,
Daniels Fredy,
Langton David,
Manolitsas Nicholas D.,
Fogarty Paul,
McDonald Christine F.
Publication year - 2001
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2001.00298.x
Subject(s) - medicine , amyloidosis , amyloid (mycology) , pathology , respiratory tract , chemotherapy , respiratory system
Respiratory tract involvement with amyloid is rare. We report eight cases of lower respiratory tract amyloidosis including a case of isolated pulmonary interstitial amyloidosis treated with chemotherapy, two cases of recurrent endobronchial amyloid with airway obstruction successfully treated with laser therapy and three cases of localized nodular pulmonary amyloidosis. The subjects with endobronchial and nodular amyloid demonstrated good long‐term survival, while those with systemic or interstitial pulmonary amyloid had progressive disease and poor survival. Circulating monoclonal immunoglobulins were identified in five of the eight cases as the likely cause of the amyloid.