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AA‐type amyloidosis in association with non‐Hodgkin's lymphoma following CMV viremia: Autopsy case
Author(s) -
Tajima Shogo,
Ushijima Tomonori,
Matuya Shoji,
Horiuchi Hajime
Publication year - 2010
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2009.02505.x
Subject(s) - amyloidosis , lymphoma , medicine , pathology , autopsy , rheumatoid arthritis , immunology
Amyloidosis in non‐Hodgkin's lymphoma (NHL) is known to be of the AL type, and AA‐type amyloidosis in NHL is extremely rare. Herein is reported an autopsy case of follicular lymphoma that transformed to diffuse large B‐cell lymphoma (DLBCL) in a relapse associated with systemic AA amyloidosis. CMV infection in an immunocompromised state with chemotherapy against DLBCL may have been involved in amyloid accumulation. The serum amyloid A (SAA)1 gene polymorphism, SAA1.2/1.3 , might have also been another factor in this case, considering the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis.