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Atypical carcinoid (neuroendocrine carcinoma) of the gingiva: Counterpart of a laryngeal tumor
Author(s) -
Abiko Yoshihiro,
Ogawa Ikuko,
Hattori Yufo,
Kusano Kaoru,
Nishimura Michiko,
Ohuchi Tomoyuki,
Abe Uichi,
Shibata Toshiyuki,
Matsuda Shinji,
Takata Takashi,
Kaku Tohru
Publication year - 2004
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2004.01598.x
Subject(s) - merkel cell carcinoma , synaptophysin , pathology , chromogranin a , carcinoma , anaplastic carcinoma , neuroendocrine differentiation , merkel cell , enolase , medicine , immunohistochemistry , neuroendocrine carcinoma , small cell carcinoma , metastasis , neuroendocrine tumors , cancer , prostate cancer
Intraoral localization of neuroendocrine carcinoma, usually called Merkel cell carcinoma, is extremely rare. A case of neuroendocrine carcinoma that was a counterpart of laryngeal neuroendocrine carcinoma but was not a Merkel cell carcinoma, occurring at the mandibular gingiva in a 69‐year‐old Japanese man, is described. The tumor formed a cauliflower‐like mass, measuring 20 × 20 mm, with a small area of necrosis. A computed tomography image showed metastasis in the right submandibular lymph node. Histopathologically, the tumor was composed of immature, small round cells that formed anastomosing trabecular nests. Few mitotic and no necrotic features were observed in the nests. Immunohistochemical studies showed positive staining for chromogranin, synaptophysin and neuron‐specific enolase in the tumor nests. We diagnosed it as an atypical carcinoid (neuroendocrine carcinoma), a counterpart to the same type of tumor occurring in the larynx. The present case is an extremely rare case of neuroendocrine carcinoma without the feature of Merkel cell carcinoma arising from the gingiva.