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Immunohistochemical characterization of a case of duodenal gangliocytic paraganglioma
Author(s) -
Furihata Mutsuo,
Sonobe Hlroshi,
Iwata Jun,
Ido Eiji,
Ohtsuki Yuji,
Ohnishi Sabum
Publication year - 1996
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1996.tb03662.x
Subject(s) - chromogranin a , immunohistochemistry , pathology , glial fibrillary acidic protein , antibody , ganglion , ampulla , biology , chemistry , anatomy , medicine , immunology
A case of duodenal gangliocytic paraganglloma (DGP) arising in the ampulla of Vater of an 84 year old male is reported. The present case shows the typical hlstological features with a mixture of epithellold, gangllon‐like and spindle cells. lmmunohistochemically, the spindle cells were positive with antibodies to neuron specific enorse, S‐100 protein and nsurofilament (NF), but negative for anti‐glial fibrillary acidic protein (GFAP), synaptophyaln and myelln basic protein (MBP). Both anti‐Leu‐7 and chromogranin A antibodies gave porritive reactions with a fine granular pattern in the epithellold cells. Most ganglion‐like cells showed the cytoplasmic lmmunorsection with GFAP and a few with NF and synapto physin. In these three tumor components, no reactivity was detected In the antibodies to the neurohormonal peptides tested. The present data are fundamentally in keeping with those previously reported, but add the immunohistochemical positivity of gangllon‐like cells for GFAP, suggesting different neuroglial differentiation.