Open AccessHistologic Changes in Graves' Thyroid Gland after 131 I Therapy for Hyperthyroidism
Author(s) -
Mizukami Yuji,
Michigishi Takatoshi,
omura Akitaka,
Hashimoto Takuma,
Noguchi Masakuni,
Ohmura Kenji,
Matsubara Fujitsugu
Publication year - 1992
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1992.tb03247.x
Subject(s) - medicine , thyroid , pathology , thyroiditis , goiter , euthyroid , immunohistochemistry , lesion , papillary carcinoma , thyroid carcinoma
The effect of 131 I therapy was examined in 13 thyroid glands affected by Graves’disease 3 to 29 years after irradiation for hyperthyroidism. All of the patients had clinically palpable thyroid nodules. Two patients were in a latent hypothyroid, 6 in a euthyroid and 5 in a hyperthyroid state. The microscopic changes in the thyroids showed a pattern of multiple adenomatous nodules with cystic changes, marked oxyphilic cell changes with nuclear atypism and various degrees of chronic thyroiditis. Immunohistochemical staining for TG and T 4 was negative to mildly positive in these oxyphilic cells and entirely negative for EGF and CEA. The DNA ploidy pattern was diploid pattern in 6 cases. One papillary‐type microcarcinoma occurred, but there was no evidence of a relationship between the tumor and the irradiation. The pathologic findings in Graves’thyroid gland after 131 I therapy are not specific, but pathologists should differentiate this lesion from adenomatous goiter, which occurs with no apparent cause, or from thyroid carcinoma because of the marked nuclear atypism of this lesion.