Open AccessINCIPIENT GERM CELL TUMOR IN SERTOLI‐CELL‐ONLY SYNDROME TESTIS, ACCOMPANIED WITH RETROPERITONEAL TERATOCARCINOMA AND WIDESPREAD METASTASES
Author(s) -
Mori Hiroshi,
Osafune Masao,
Matsumiya Kiyomi,
Fujioka Hideki,
Mizumoto Seigo,
Inafuku Sadamitsu,
Ueno Hiroshi,
Chatani Fumio,
Okano Kinya
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb00216.x
Subject(s) - teratocarcinoma , sertoli cell , germ cell , pathology , medicine , embryonal carcinoma , biology , cancer research , spermatogenesis , cellular differentiation , genetics , gene
Incipient germ cell tumor in Sertoli-cell-only syndrome testis was examined in an autopsy case of retroperitoneal teratocarcinoma with widespread metastases. Although both testes of a 28-year-old man had clinically been small and free from tumor mass to palpation, histopathological examinations revealed a malignancy in the right testis with the appearance of Sertoli-cell-only syndrome. The left testis showed solely the histology of Sertoli-cell-only syndrome. The testicular malignancy consisted of undifferentiated, atypical germ cells mainly confined within approximately one-tenth of seminiferous tubules, and only one small cartilage nodule. Some tubules showed intratubular growth pattern suggestive of seminoma. A few syncytiotrophoblast-like giant cells occurred in the tubules. These findings seem to furnish substantial evidence to the concept that atypical germ cells are the origin of testicular germ cell tumors of different types.