Open AccessEXPERIMENTAL STUDIES ON HEPATIC CIRRHOSIS AND HEPATOCARCINOGENESIS
Author(s) -
Shimizu Akio
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb00213.x
Subject(s) - cirrhosis , medicine , basal (medicine) , gastroenterology , nodule (geology) , pathology , furfural , carcinogen , endocrinology , chemistry , biology , biochemistry , paleontology , insulin , catalysis
The effects of hepatic cirrhosis on chemical hepatocarcinogenesis were studied in rats using an experimental model for hepatic cirrhosis established by chronic furfural administration (described in a previous report 19 ) and N‐2‐fluorenylacetamide (2‐FAA). Sixteen male Wistar rats were fed with 2‐FAA feeding 3 cycles, which consisted of 3 weeks consuming 0.03% 2‐FAA diet and 1 week basal diet, after 120 days of furfural feeding. Grossly and his‐tologically all livers of experimental animals showed formation of multiple hyperplastic nodules with atypical features in parts. These hyperplastic nodules were positively immunostained with alpha fetoprotein. On the other hand, none of the livers of 16 rats fed with furfural alone showed formation of hyperplastic changes and only 2 livers of 16 rats fed 2‐FAA without preadministration of furfural showed one small hyperplastic nodule each, respectively. These results indicate that the cirrhotic liver induced by chronic furfural feeding has an enhancing effect on 2‐FAA chemical hepatocarcinogenesis, and suggests that the presence of hepatic cirrhosis induces Increased susceptibility to hepatocarcinogenic stimuli.