Open AccessPANCREATIC CARCINOMA IN CHILDHOOD: Report of an Autopsy Case and a Review of the Literature
Author(s) -
Ohaki Yoshiharu,
Misugi Kazuaki,
Sasaki Yoshiro,
Okudaira Masahiko
Publication year - 1985
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1985.tb01451.x
Subject(s) - autopsy , pathology , pancreatic carcinoma , carcinoma , medicine , general surgery , pancreatic cancer , cancer
Clinical and histological findings of pancreatic carcinoma in a 6‐year‐old boy are reported. Gradual change of histological appearance of the tumor during his course of 3 years and elevation of serum alpha‐1‐fetoprotein (AFP) are documented. Two biopsy specimens showed immature histological appearance compatible with pancreatoblastoma, and autopsy material showed well‐differentiated adenocarcinoma with distinct ductal and acinar differentiation. Electron microscopy demonstrated zymogen‐like granules in the apical portion of the neoplastic cells. Immunoperoxidase method demonstrated AFP in the neoplastic cells in addition to alpha‐1‐antitrypsin. Literature of pancreatic tumor in the young was reviewed, and characteristics of this case were discussed. ACTA PATHOL. JPN. 35 : 1543–1554, 1985.