Open AccessCHRONIC MYELOCYTIC LEUKEMIA WITH MARKED MYELOFIBROSIS and OSTEOSCLEROSIS
Author(s) -
Honma Keiichi,
Nemoto Keiichi,
Ohnishi Yoshihisa
Publication year - 1983
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1983.tb00366.x
Subject(s) - osteosclerosis , myelofibrosis , medicine , myelocytic leukemia , busulfan , pathology , autopsy , myeloid leukemia , extramedullary hematopoiesis , leukemia , bone marrow , disease , haematopoiesis , hematopoietic stem cell transplantation , stem cell , biology , genetics
An autopsy case of a 50 years old woman who manifested chronic myelocytic leukemia (CML) with secondary myelofibrosis (SMF) is reported. The interesting point of this case was a marked diffuse myelofibrosis (MF) with osteosclerosis, so that it was difficult to make a diagnosis of either CML or idiopathic myelofibrosis (IMF), but both clinical and histological findings supported the diagnosis of CML with SMF. Her long term busulfan therapy was suspected as being the cause of this severe MF. The relationship of CML and IMF was also discussed.