Open AccessGLOMERULAR LESIONS IN MULTIPLE MYELOMA
Author(s) -
Tange Tsuyoshi,
Kurumado Katsumaro,
Nakazawa Masaki,
Imamura Yukio,
Kosaka Kinori,
Kawaoi Akira
Publication year - 1978
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1978.tb00545.x
Subject(s) - multiple myeloma , pathology , medicine
An autopsy case of multiple myeloma (IgG, lambda type), clinically characterized by decreased glomerular filtration rate, is reported with particular emphasis on changes in the glomeruli of kidneys. Histologically, the glomeruli revealed slight increase in mesangial matrix and focal thickening of tuft capillary wall. Electron‐microscopically, deposits were observed in a subendothelial location in the glomerular capillary walls, and inclusions were noted in the cytoplasm of the visceral epithelial cells. Histoimmunofluo‐rescent study of the kidney demonstrated intense focal and slight diffuse positivity against labelled antisera of anti‐IgG and anti‐lambda type of light chain on the capillary wall of the glomerular tufts. Other immunoglobulins were not demonstrable in capillary walls. These findings represent the intraglomerular deposition of paraprotein of multiple myeloma without amyloidosis.