Open Access
PLASMA FREE FATTY ACID and ACUTE VASCULAR INJURY
Author(s) -
Numano Fujio,
Kobayashi Masahiko,
Moriya Kinya,
Numano Fujie,
Shimamoto Takio
Publication year - 1973
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1973.tb02774.x
Subject(s) - oleic acid , epinephrine , cholesterol , medicine , aorta , endocrinology , heparin , fatty acid , chemistry , biochemistry
One‐shot treatment of atherogenic substances, such as cholesterol, animal fat, adrenalin or cigarette smoking to animals induces “acute vascular injury” characterized histologically by swollen endothelial cells and edematous changes in subendothelial layer and upper part of media of aorta (Shimamoto et al., 1960), the cause of which is still unknown. Most of these atherogenic substances or procedures are known to increase the level of free fatty acid (FFA) in serum and the possibility of FFA as a direct attacker to induce this edematous change in arterial wall was studied. Oral administration of oleic acid (2 g/kg), intravenous injection of angiotensin II (10 γ/kg or 1 γ/kg) or heparin (200 unit/kg), intramuscular injection of AGTH (10 unit) or concomitant administration of cholesterol (2 g/kg) and epinephrine (1 γ/kg) or oleic acid (2 g/kg) and epinephrine (1 γ/kg) were performed in 21 rabbits and histological features of aortic wall of each treated rabbit were compared with those of 6 placebo control rabbits, all of which were sacrificed 2 hours after treatment. All treated rabbits exhibited a statistically significant increase of serum free fatty acid, compared with that before treatment. Serum cholesterol level did not change after these treatments. Histological examination, however, revealed a typical edematous change in aortic wall of rabbits treated with angiotensin II or cholesterol and epinephrine. Those treated with ACTH, heparin or oleic acid, did not exhibit such pathological changes in their aortic wall. These different histological findings suggest that the elevation of plasma FFA was not a direct offender to acute vascular injury in aortic wall.