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Glial Fibrillary Acidic Protein in Tuberous Sclerosis
Author(s) -
Tobo Mizue,
Mitsuyama Yoshio,
Kaku Tsunehisa
Publication year - 1983
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1983.tb00307.x
Subject(s) - tuberous sclerosis , glial fibrillary acidic protein , immunoperoxidase , subependymal zone , gfap stain , giant cell , pathology , biology , astrocyte , white matter , medicine , immunology , immunohistochemistry , central nervous system , neuroscience , antibody , magnetic resonance imaging , monoclonal antibody , radiology
Abstract: We examined two cases of tuberous sclerosis for the presence of glial fibrillary acidic protein (GFAP) using the immunoperoxidase technique. The majority of abnormal giant cells in the cerebral cortex showed no reaction to anti‐GFAP. Some abnormal cells in the cortical tuber and white matter showed a weak positive reaction. All of the subependymal tumor cells showed no GFAP in their cytoplasm. The abnormal giant cells in tuberous sclerosis,. morphologically similar to gemistocytic astrocyte, are not accompanied by antigenic properties of GFAP.