A Clinical and Electroencephalographic Study on Anti‐Epileptic Activity of Clonazepam

SUMMARY The anti‐epileptic activity of clonazepam was evaluated, based on the relationship between clinical effects of the long‐term oral administration and electroencephalo‐graphic effects of the intravenous administration.1 . There were 13 patients who could undergo both oral and intravenous administration. Both results correlated roughly. 2 . In a clinically ineffective case with tonic clonic convulsion, EEG findings were aggravated after the intravenous injection of clonazepam. The possibility of inducing the clinical seizures by clonazepam was discussed. 3 . Since clonazepam was clinically effective in the Jacksonian type by oral administration and suppressed secondary generalized discharge on the EEG by intravenous administration, it was considered that this drug will be clinically effective for secondary generalization. 4 . Clonazepam was most clinically effective on complex partial seizures by oral administration and suppressed remarkably temporal spikes by intravenous injection. It can be suggested that clonazepam has specific effects on complex partial seizures. 5 . Clonazepam suppressed remarkably the photosensitivity on the EEG by intravenous injection and was effective over a long time on the photosensitive epilepsy by oral administration. Clonazepam was considered to be a beneficial drug for the photosensitive epilepsy.