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Effect of 7‐Bromo‐5‐(2‐pyridyl)‐3H‐l, 4‐benzodiazepine‐2(1H)‐one, Bromazepam (Ro 5–3350), a New Minor Tranquilizer, on Psychoneurosis with Special Reference to the Obsessive‐Compulsive Symptoms
Author(s) -
OKUMA Teruo,
NAKAO Takehisa,
OGURA Chikara,
KISHIMOTO Akira,
MAJIMA Kazuaki
Publication year - 1971
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1971.tb01502.x
Subject(s) - bromazepam , tranquilizer , benzodiazepine , minor (academic) , psychology , psychiatry , medicine , philosophy , receptor , humanities
Summary Clinical application of a minor tranquilizer bromazepam, 7‐Bromo‐5‐(2‐pyridyl)‐3H‐1,4‐benzodiazepine‐2(lH)‐one (Ro 5–3350) was made on 18 cases of obsessive‐compulsive neurosis, 10 of anxiety neurosis, 6 hypochondriasis, 4 hysteria and 3 of phobia of bodily odor.1) In 18 cases of obsessive‐compulsive neurosis, bromazepam was found markedly effective in 6, effective in 3, fairly effective in 5, ineffective in 2, and aggravated in 2 cases. The effective cases were those with obsessive thinking and manifest anxiety. In other kind of neurosis, bromazepam was markedly effective in 5 and effective in 2 of 10 anxiety neurotic cases, whereas it was almost ineffective in the cases of hypochondriasis, hysteria and phobia of bodily odor. 3) The maximum daily dose of bromazepam was 10 to 20 mg in many cases, and 20 to 30 mg in some other cases. The durg is quick‐acting to such an extent that it took 2 to 5 days for its action to become manifest in markedly effective cases. 4) Various laboratory tests revealed no appreciable abnormality in most cases where bromazepam was employed. Physical side effects such as slight hypotension, dizziness, and sleepiness were observed in a few cases, and mental side effects such as loquaciousness and restlessness in about 20 cases. 5) The target symptoms of bromazepam were suggested to be anxiety, tension, and irritation like previously reported other benzodiazepines. The fact that its action of relieving anxiety and tension and of elevating mood was found to be more potent than those of other benzodiazepines and that it was effective on some obsessive‐compulsive neurosis that showed little response to other benzodiazepines, suggested that bromazepam is a potent and characteristic new minor tranquilizer of clinical value.