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Acute interstitial nephritis due to mesalazine
Author(s) -
TADIC MARIO,
GRGUREVIC IVICA,
SCUKANECSPOLJAR MIRA,
BOZIC BORKA,
MARUSIC SRECKO,
HORVATIC IVICA,
GALESIC KRESIMIR
Publication year - 2005
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2005.00376.x
Subject(s) - medicine , mesalazine , interstitial nephritis , nephritis , gastroenterology , inflammatory bowel disease , kidney , disease
SUMMARY: A case of mesalazine‐induced acute interstitial nephritis (AIN) in a 41‐year‐old patient with ulcerative colitis (UC) is reported here. Clinical symptoms such as fever and arthralgia, and laboratory findings such as eosinophilia and renal failure suggested AIN, which was confirmed by biopsy. With withdrawal of mesalazine and intravenous methylprednisolone the patient's renal function was recovered. It is observed that early discontinuation of mesalazine is associated with amelioration of interstitial nephritis in most patients, so the recommendation is that patients receiving mesalazine should undergo routine monitoring of renal function. Delayed diagnosis may lead to permanent renal function impairment.