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Comparison of the effect of amphotericin B desoxycholate and amphotericin B colloidal dispersion on renal functions and renal morphology in rats
Author(s) -
DOUBEK MICHAEL,
MAYER JIRI,
LAUSCHOVA IRENA,
SCHEER PETER,
KREJCIROVA LENKA,
HORKY DRAHOMIR,
DOUBEK JAROSLAV
Publication year - 2005
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2005.00339.x
Subject(s) - amphotericin b , nephrotoxicity , medicine , kidney , renal function , nephrosis , pharmacology , pathology , antifungal , dermatology
SUMMARY: Background and Aim: Amphotericin B (AmB) desoxycholate remains as one of the most efficacious agents currently available for the treatment of systemic fungal infections; however, amphotericin B colloidal dispersion (ABCD) has been developed because of AmB desoxycholate nephrotoxicity. The goal of our study was to compare the effect of administration of AmB desoxycholate and ABCD on renal functions and renal morphology in rats. Results: Amophotericin B desoxycholate as well as ABCD causes damage to renal tubuli and polyuria. Amophotericin desoxycholate causes considerably more severe damage to tubuli than ABCD, but the morphological damage to renal glomeruli is minimal in both formulas. In tubular cells, AmB desoxycholate causes severe damage to mitochondria, vacuolation of cytoplasm, and increased values of volume density of peroxisomes. Conclusion: None of these formulas causes a decrease in glomerular filtration in rats when animals are properly hydrated.