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Extracellular matrix, growth factors and their interactions in the pathogenesis of diabetic kidney disease
Author(s) -
GILBERT Richard E,
COOPER Mark E,
JERUMS George
Publication year - 1996
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.1996.tb00105.x
Subject(s) - extracellular matrix , pathogenesis , diabetic nephropathy , medicine , glomerulosclerosis , microbiology and biotechnology , disease , diabetes mellitus , function (biology) , extracellular , glomerulus , kidney , pathology , biology , endocrinology , proteinuria
Summary: The accumulation of extracellular matrix (ECM) within the glomerulus is the ultrastructural hallmark of diabetic nephropathy and is directly linked to the declining renal function. the pathogenesis of these ECM changes in diabetes is not well understood but is likely to involve interaction between cells, growth factors, structural proteins and cell receptors for these molecules. Recent advances in cellular and molecular biology have highlighted the complex nature of the molecular interactions which may lead to glomerulosclerosis in diabetes.