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Changes in biliary excretory mechanisms in rats with ethinyloestradiol‐induced cholestasis
Author(s) -
TAKIKAWA HAJIME,
TAKAMORI YORIYUKI,
SANO NAOYO,
KUYAMA YASUSHI,
YAMANAKA MASAMI
Publication year - 1998
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1998.tb00636.x
Subject(s) - excretory system , excretion , cholestasis , medicine , endocrinology , p glycoprotein , chemistry , antibiotics , biochemistry , multiple drug resistance
ABSTRACT Several excretory pathways for cholephilic compounds have been known. To examine the changes in excretory pathways in cholestasis induced by ethinyloestradiol, various bile acids, organic anions and organic cations were intravenously administered to ethinyloestradiol‐treated rats and their biliary excretion was studied. Biliary excretion of taurocholate was slightly delayed, but its excretory maximum was markedly decreased. Biliary excretion of lithocholate‐3‐ O ‐glucuronide, leukotriene C 4 , sulphobromophthalein and pravastatin was markedly impaired to a similar extent. Biliary excretion of vinblastine, a P ‐glycoprotein substrate, was increased, suggesting increased expression of P ‐glycoprotein. In contrast, biliary excretion of erythromycin, a cationic antibiotic, was markedly impaired. In conclusion, ethinyloestradiol treatment altered the biliary excretion of organic compounds, which may partly be related to changes of the canalicular transporters.