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SHORT‐ AND LONG‐TERM INTAKE OF WHEAT ALBUMIN AFFECTS BLOOD GLUCOSE AND HbA1c LEVELS IN HEALTHY AND TYPE 2 DIABETIC SUBJECTS
Author(s) -
Aiso Yoshitaka,
Ishiyama Tetsuya,
Sekino Hisakuni,
Nomura Masaomi,
Kobayakawa Akira,
Higashimoto Keiji,
Inoue Yasuyuki,
Ikami Takao,
Sawai Kiichi,
Ikeda Yoshio
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04791.x
Subject(s) - postprandial , medicine , endocrinology , albumin , diabetes mellitus , meal , placebo , glucose tolerance test , type 2 diabetes , insulin resistance , alternative medicine , pathology
SUMMARY1 0.19‐Wheat albumin has powerful inhibitory effects on human pancreatic and salivary amylases. 2 To examine the effects on blood glucose control of the test food – powdered soup containing 125 mg 0.19‐wheat albumin – two studies were conducted. In study 1, the test food or a placebo was given with a normal meal to 10 volunteers in a cross‐over manner, and in study 2, the test food was given to 14 male and 7 female subjects with mild type 2 diabetes mellitus three times a day for 12 weeks. 3 In study 1, a significant inhibitory effect ( P < 0.05) on increase in blood glucose was observed 40 min and 1 h after administration of the test food. In subjects with a relatively higher fasting blood glucose, there was a greater inhibitory effect. 4 In study 2, a significant reduction ( P < 0.05) in mean haemoglobin A1c (HbA1c) level was observed 8 and 12 weeks after administration of the test food. In subjects with a higher baseline HbA1c level ( 7.0), there was a more obvious reduction. 5 These results indicate that suppression of postprandial blood glucose levels by 0.19‐wheat albumin helps moderate absorption of glucose and support long‐term blood glucose control.