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MECHANICAL BONE PROPERTIES OF OBESE MODEL SHR/NDmcr‐cp RATS
Author(s) -
Nishii Naomi,
Arai Michitsugu,
Togari Akifumi,
Nakabayashi Toshikatsu
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04767.x
Subject(s) - endocrinology , medicine
SUMMARY1 High‐blood pressure or diabetes may be related to the loss of bone mass or the development of osteoporosis. We examined the mechanical bone properties of the SHR/NDmcr‐cp (SHR‐cp) rat, an obese strain that develops hypertension, hyperlipidaemia and insulin‐independent diabetes. 2 The mechanical properties of the femur of 22‐week‐old Wistar‐Kyoto (WKY) and SHR‐cp rats were measured by Peng's three‐point bending procedure modified by Shintani. Femurs were then defatted and dried. After weighing, the dried bones were ashed and the ash was weighed. The values of the dry weight, ash weight and ash weight/dry weight (%) were used as a description of the physical parameters of the bone. 3 All values of stiffness, strength, toughness and ductility in SHR‐cp were significantly lower than those of WKY rats ( P < 0.05). The value of ash weight/dry weight (%) was lower in SHR‐cp rats ( P < 0.01). These results showed that bone fragility was greater in SHR‐cp rats, indicative of osteopenia.