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COMPARATIVE HAEMODYNAMIC STUDIES OF ENDOTHELIN‐1, ‐2 AND ‐3 ON CONSCIOUS SHRSP AND WKY
Author(s) -
Higashino H.,
Simeonova K.,
Lambev I.,
Suzuki A.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02880.x
Subject(s) - medicine , endothelin receptor , endothelins , endocrinology , vasodilation , endothelin 1 , hemodynamics , endothelin 3 , blood pressure , receptor
Summary 1. Depressor and pressor effects of endothelin‐1, ‐2 and ‐3 in relation to hypertension were investigated in conscious WKY and SHRSP. 2. Changes of systolic arterial pressure to both depressor and pressor responses caused by three doses of endothelin‐1, ‐2 or ‐3 (0.1, 0.3 and 1 nmol/kg) occurred to a similar extent between WKY and SHRSP. These data showed that endothelins may not exert an important role on the pathogenesis of hypertension. 3. Endothelin‐1 decreased the cardiac index more in SHRSP than in WKY, indicating the dominance of ETA receptors in SHRSP compared with WKY. 4. ET‐1 was the most potent vasodepressor and vasodilator of three endothelin peptides in rats. 5. During the pressor responses to endothelin‐1 and ‐3, cardiac arrhythmia was observed with high frequency in the animals of both groups, indicating the arrhythmogenic effect of ET.