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RECEPTORS AND STEROID‐DEPENDENT HYPERTENSION
Author(s) -
Coghlan John P.,
Reid Amanda F.,
Spence Campbell D.,
Scoggins Bruce A.,
Whitworth Judith A.
Publication year - 1988
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1988.tb01058.x
Subject(s) - mineralocorticoid , steroid , endocrinology , glucocorticoid , receptor , glucocorticoid receptor , essential hypertension , medicine , aldosterone , mineralocorticoid receptor , steroid hormone , peripheral , pharmacology , blood pressure , hormone
SUMMARY 1. Repeated observations indicate that ACTH administration causes hypertension. 2. Development of hypertension requires 17α‐hydroxyprogesterone and 17α, 20α‐dihydroxy‐4‐pregnene‐3‐one to be present in association with other steroids. 3. The hypertensinogenic activity of corticosteroids is distinct from their glucocorticoid and mineralocorticoid effects. 4. The location of central and peripheral receptors for this hypertensinogenic activity is not clear. 5. The physiological mechanisms that mediate the response are unknown, though a number of potential mediating effects has been demonstrated. 6. The overall importance of unusual steroids and steroid actions in human essential hypertension still requires elucidation.