Premium
RELATIONSHIP BETWEEN PLATELET CYTOSOLIC FREE CALCIUM CONCENTRATION AND PLASMA RENIN ACTIVITY
Author(s) -
Sang Kim Hahn Le Quan,
Elghozi JeanLuc,
Meyer Philippe,
Devynck MarieAude
Publication year - 1987
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1987.tb00373.x
Subject(s) - endocrinology , plasma renin activity , medicine , chemistry , calcium , renin–angiotensin system , cytosol , platelet , sodium , angiotensin ii , biochemistry , blood pressure , enzyme , organic chemistry
SUMMARY 1. Plasma renin activity (PRA) and platelet cytosolic free calcium concentration ([Ca 2+ ] i ) were simultaneously determined in 18 untreated essential hypertensive subjects and 17 normotensive controls. A significant positive correlation was found between [Ca 2+ ] i and PRA (slope = 42 nmol/l/ng/ml/h) in these 35 subjects. 2. Two determinations more than one week apart in nine subjects confirmed the parallel fluctuations of [Ca 2+ ] i and PRA. A strict sodium restriction produced a progressive PRA elevation associated with a parallel rise in [Ca 2+ ] i in one subject. 3. These results are consistent with the hypothesis that angiotensin II causes a concentration‐dependent calcium mobilization.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom