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EFFECTS OF THE INTRAPERITONEAL ADMINISTRATION OF DIAZEPAM ON RAT SERUM LIPOPROTEINS SEPARATED BY POLYACRYLAMIDE GEL ELECTROPHORESIS
Author(s) -
Cuparencu B.,
Tomus C.,
Horák J.,
Nan A.,
Cordos M.,
Puia L.,
A M.,
Marino E.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00913.x
Subject(s) - diazepam , intraperitoneal injection , cholesterol , medicine , total cholesterol , chemistry , endocrinology , blood lipids , lipoprotein , high density lipoprotein , polyacrylamide gel electrophoresis , pharmacology , biochemistry , enzyme
SUMMARY 1. In normolipidaemic young rats the intraperitoneal administration of diazepam (10 mg/kg) induced a marked fall of the total serum lipids and total cholesterol. A dose of 5 mg/kg brought about an increase of HDL 2 lipoprotein fraction and an elevation of the HDL 2 /HDL 2 .HDL 3 ratio. 2. Margarine administration elicited a significant augmentation of the total serum lipids and a reduction of the HDL 2 /HDL 2 .HDL 3 ratio. The intraperitoneal injection of diazepam in margarine‐treated rats brought about a decrease of total serum lipids and total cholesterol, (when compared to the margarine values), an obvious elevation of the HDL 2 fraction and of HDL 2 /HDL 2 .HDL 3 ratio. The LDL, (β) fraction was decreased. 3. These data confirm our earlier findings which show that diazepam improves the HDL cholesterol/total cholesterol ratio.