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SEPARATION OF TWO CONJUGATES OF CLOFJBRIC ACID (CPIB) FOUND IN THE URINE OF SUBJECTS TAKING CLOFIBRATE
Author(s) -
Faed Ellen M.,
McQueen E. G.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00671.x
Subject(s) - clofibrate , urine , conjugate , chromatography , chemistry , hydrolysis , thin layer chromatography , metabolite , biochemistry , mathematics , mathematical analysis
SUMMARY 1. Two main conjugates of CPIB (2‐[chlorophenoxy]‐2‐methylpropionic acid) are present in the urine of subjects taking clofibrate. The metabolites can be separated by thin‐layer chromatography (TLC). 2. Both conjugates are hydrolysed by dilute alkali, but only one is hydrolysed by the enzyme β‐glucuronidase. In eighty‐five urine specimens this conjugate accounted for an average of 54.5% (range 25–70%) of the total CPIB, while 2.6–12.45% (mean 5.1%) was present as free CPIB.