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CYCLIC 3′5′‐ADENOSINE MONOPHOSPHATE AND CENTRAL CIRCULATORY CONTROL IN CATS AND DOGS
Author(s) -
Delbarre B.,
Se Danielle,
Schmitt H.
Publication year - 1977
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1977.tb02671.x
Subject(s) - medicine , endocrinology , heart rate , blood pressure , circulatory system , theophylline , adenosine , chronotropic , ventricle , somatostatin , chemistry
SUMMARY 1. Dibutyryl cyclic AMP (Db CAMP, 75–500 μg/kg), injected into the lateral ventricle of the brain of the cat increased blood pressure, heart rate and splanchnic discharge rate. 2. ATP, but not AMP, induced similar changes; GMP in small doses increased blood pressure. 3. A number of drugs are known to activate adenylate cyclase‐induced hypertension, tachycardia and increase splanchnic discharge rate. This was shown for TRH, tetracosactide and a new β 2 ‐adrenoceptor stimulant, NAB 365. 4. Injection into the lateral ventricle of theophylline or Ro 7/ 2956, both inhibitors of phosphodiesterase, similarly increased blood pressure. 5. Histamine administered by the same route induced similar reactions; it is not known if this action was exerted by activation of H 1 ‐ or H 2 ‐receptors. 6. Somatostatin, known to reduce cAMP levels, induced a small but significant decrease in blood pressure. Melanocyte stimulating hormone release inhibiting factor (MIF) and TSH were ineffective. 7. These results provide evidence for the possibility of a role for cAMP in the central regulation of blood pressure at suprabulbar levels.