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UNUSUAL EFFECT OF SOME α‐MERCAPTOACRYLIC ACIDS ON METABOLISM OF ZINC IN THE RAT
Author(s) -
Prakash N. J.,
Schechter Paul J.,
Giroux Eugene,
Sjoerdsma Albert
Publication year - 1977
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1977.tb02373.x
Subject(s) - zinc , metabolism , chemistry , biochemistry , medicine , organic chemistry
SUMMARY 1. Gavage of rats with β‐aryl derivatives of α‐mercaptoacrylic acid resulted in pronounced and sustained elevation of serum zinc concentration. Greater than ten‐fold increases above normal zinc levels were attained 2–8 h after doses of 50 mg/kg of the phenyl and furan derivatives. 2. These compounds were rapidly absorbed from the rat gastrointestinal tract and could be detected in serum for several days after a single dose. The return of serum zinc concentration to the normal level paralleled clearance of the mercaptoacrylic acid from plasma. 3. Close to 100% of the zinc and of the α‐mercapto‐β‐(2‐furan)acrylic acid (MFA) in serum 4 h after administration of the compound were bound to serum macromolecules. 4. MFA decreased excretion of endogenous zinc; it altered neither the gastrointestinal absorption of zinc nor serum concentrations of copper, albumin and total protein. 5. These compounds appear to mobilize zinc from tissue stores and retard zinc clearance from plasma.