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Generalized flare of pustular psoriasis induced by PEGylated interferon‐α2b therapy for chronic hepatitis C
Author(s) -
Wu MengChi,
Lee J YuYun
Publication year - 2012
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2011.00767.x
Subject(s) - medicine , psoriasis , pustular psoriasis , dermatology , rash , exacerbation , pegylated interferon , interferon , generalized pustular psoriasis , hepatitis , acne , immunology , chronic hepatitis , virus , ribavirin
New onset or exacerbation of psoriasis vulgaris has been reported in a small number of patients after interferon (IFN)‐α therapy. Herein, we report a case of generalized flare of pustular psoriasis induced by PEGylated IFN‐α2b (PEG‐IFN‐α2b) in a 59‐year‐old woman with a 15‐year history of pustular psoriasis and chronic hepatitis C. Interferon‐α therapy was discontinued and the rash resolved after treatment with cyclosporin and systemic methylprednisolone. The potential side effect of PEG‐IFN‐α2b in inducing or exacerbating psoriasis should be kept in mind when treating patients with a history of psoriasis or pustular psoriasis.