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Rhinocerebral zygomycosis caused by Saksenae vasiformis in a diabetic patient
Author(s) -
GarcíaMartínez Jesús,
LópezMedrano Francisco,
Alhambra Almudena,
Del Palacio Amalia
Publication year - 2008
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2008.01513.x
Subject(s) - diabetic ketoacidosis , zygomycosis , medicine , pathological , mucormycosis , diabetes mellitus , biopsy , surgery , debridement (dental) , amphotericin b , pathology , dermatology , antifungal , endocrinology
Summary We report a rare case of invasive rhinocerebral Saksenae vasiformis infection in a 71‐year‐old man with type 2 diabetes mellitus ketoacidosis. Combined histological and microbiological examination of two biopsy specimens taken at four days' intervals showed broad non‐septate hyphae on direct smears of biopsies and necrosis and angioinvasion by hyphae were seen in the tissue. S. vasiformis was cultured from both biopsies. The patient had a fatal outcome even though partial debridement, liposomal amphotericin B treatment and control of diabetes were instituted. Permission for necropsy was denied. Clinical, epidemiological and pathological features of the case and manifestations of S. vasiformis infections are discussed. Most cases involve cutaneous sites and only two cases of rhinocerebral infections (both with fatal outcome) have been described. The present case is the third documented case of involvement of the sinuses and the second case of S. vasiformis infection documented in Europe.