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A New Combination of Tolnaphtate and Methylpartricine (SPA‐S‐345, Tritol®) for Mycotic Skin Infections
Author(s) -
Lowy M.,
Parent D.,
LedouxCorbusier M.
Publication year - 1985
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.1985.tb02158.x
Subject(s) - candida albicans , medicine , candida infections , gynecology , dermatology , microbiology and biotechnology , biology
Summary: A combination of tohaphtate and methylparhicine (SPA‐S‐345) was used in the treatment of mycotic skin infections. Treament consisted in the topical application of a ueam or fotton contrining SPA‐S‐345. The aim of this sine was to test dinia a combination of drugs Mcb are active both m vitro and in vivo against dermrtophytes and Pityrospomm furfur (Tolnaphtate) and against Candida species (methylpnrtricine). The study comprised 34 patients witb the following pathogenic agents: 3 species of dennatophytes, Candida albicans and Pstyrospo nunfdw. Before and after treatment, direct microscopical examination and cnlture of the finpi were performed. After three weeks of treatment, particularly good clinical results were obtained in cases of infection by dermatophytes and Candida, 26 patients out of the 34 treated in this shdy were completely cured. Zusammenfassung: Eine Kombiion von Tolnnffnt md Methylpartrizin (SPA‐S‐345) wurde zur Behandlung von Hautmykosen eingesetzL Das Medikament he Su5efich ak Creme oder lntio adgetragen. Bei dieser untersnrhnng Sonte die klinisdte W‐ der beiden Anti‐mykotika festgestellt werden, die im Fde des Ibhaht in vitm and in vivo gegen Dermatophy‐ten‐ nnd Pitgrosponun‐Arten wirksam sind und im Fall des Methgtpartrizin gegen Candida‐Arten. Die Untersuchung wurde an 34 Patlenten ddgefiihrt, bei denen folgende Emger festgestellt den: drei Dernutophytexmten, Curdida albicans md Pityrosponun khr. Vor md nr& der Behandlung den mhoskopisrhe and knlhuelle Untersncbungen durChgefhrt. Nach dreiwikldger Be!handhng wnrden besonders gate Ergebnisse bei Patienten mit Dermato‐phyten‐ und Candida‐Infektionen gesehen. Insgesamt wurden 26 von 34 behandelten Patienten geheiit.

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