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Plasma testosterone in adult normoglycaemic men: impact of hyperinsulinaemia
Author(s) -
Praveen E. P.,
Khurana M. L.,
Kulshreshtha B.,
Dwivedi S. N.,
Prabhakaran D.,
Khadgawat R.,
Gupta N.,
Kumar G.,
Ammini A. C.
Publication year - 2012
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2012.01278.x
Subject(s) - medicine , endocrinology , testosterone (patch) , insulin , c peptide , hormone , waist–hip ratio , type 2 diabetes , hyperinsulinemia , insulin resistance , diabetes mellitus , body mass index , waist
Summary This study analysed the relationship of plasma testosterone with β‐cell secretion, insulin sensitivity and other pituitary‐target gland hormones in normoglycaemic adult men. The sample frame was the ‘ O ffspring of individuals with diabetes study’ database. A total of 358 offspring of individuals with type‐2 diabetes (T2 DM ) and 287 individuals without known family history of T 2 DM were recruited for the study. Normoglycaemic men aged ≥18 years (maximum 55) were selected for this analysis. All participants underwent 75 g oral glucose tolerance test ( OGTT ); blood samples were collected at 0, 30, 60 and 120 min for plasma insulin and C ‐peptide. Total testosterone, cortisol, adrenocorticotropic hormone, thyroid stimulating hormone and thyroxine ( T 4) were measured in the fasting sample. A total of 164 men (age 28 ± 7.7 years) were included in analysis. Testosterone correlated negatively with BMI , waist to hip ratio ( WHR ), area under curve ( AUC ) of C ‐peptide and insulin (during OGTT ) and was positively correlated with insulin sensitivity ( r ~ 0.4). Cortisol and T 4 positively correlated (weak) with testosterone ( r ~ 0.2). In multivariate analysis, AUC C ‐peptide, BMI , WHR (negatively) and cortisol (positively) were related to testosterone. Concluding, testosterone correlated negatively with BMI and β‐cell secretion. There was a positive association of testosterone with insulin sensitivity, cortisol and T4.