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Efficacy of alfuzosin and sildenafil combination in male patients with lower urinary tract symptoms
Author(s) -
Öztürk M. İ.,
Kalkan S.,
Koca O.,
Güneş M.,
Akyüz M.,
Karaman M. I.
Publication year - 2012
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2011.01268.x
Subject(s) - alfuzosin , lower urinary tract symptoms , medicine , international prostate symptom score , urology , erectile dysfunction , sildenafil , prostate , quality of life (healthcare) , hyperplasia , nursing , cancer
Summary Lower urinary tract symptoms ( LUTS ) and erectile dysfunction ( ED ) are frequently encountered in ageing males. We compared the efficacy of alfuzosin 10 mg alone or in combination with sildenafil 50 mg in the treatment of LUTS due to benign prostatic hyperplasia. One hundred male patients older than 45 years were randomized to two groups containing 50 patients each; one group receiving alfuzosin 10 mg and the other group alfuzosin 10 mg combined with sildenafil 50 mg. International Prostate Symptom Score ( IPSS ), quality of life (QoL), maximum flow rate ( Q max ), prostate volume and post‐void residual urine were evaluated. The mean age was 60.2 ± 17.8. Mean data of evaluated parameters in both groups at the end of 3rd month compared with baseline values are given respective order as; 5.1 (26.8%) and 5.8 (28.2%) points decreases in IPSS ; 1.6 (41.1%) and 1.8 (45%) points decreases in QoL; and 3.4 (29.6%) and 3.4 (33%) points increases in Q max . The outcomes of our study cannot be interpreted in such a way to report that alpha blocker‐ PDE 5 inhibitor combination has a better efficacy than alpha blocker treatment alone in patients with LUTS .