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Methylenetetrahydrofolate reductase C677T polymorphism is not associated with male infertility in a South Indian population
Author(s) -
Vani G. T.,
Mukesh N.,
Rama Devi P.,
Usha Rani P.,
Reddy P. P.
Publication year - 2012
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2011.01172.x
Subject(s) - methylenetetrahydrofolate reductase , infertility , male infertility , genotype , odds ratio , polymorphism (computer science) , gynecology , medicine , genetics , biology , gene , pregnancy
Summary Previous studies have revealed that genetic factors may be involved in regulating the mechanism of infertility, e.g., MTHFR gene polymorphism in the development of male infertility. The aim of this study is to examine whether an association exists between MTHFR C677T polymorphism and male infertility. The study was carried out by means of a PCR‐RFLP assay in 206 infertile men and 230 ethnically matched controls. The statistical analysis using two‐sided Fisher’s exact test and Pearson chi‐squared test showed CT genotype is associated nonsignificantly with male infertility (OR = 1.19, 95% CI = 0.71–1.97). Because of the lack of TT homozygotes in the controls, a combined odds ratio of CT and TT homozygotes against the control has been calculated (OR = 1.36, 95% CI = 0.83–2.22), and the same was insignificant. The overall results of the study indicate that MTHFR C677T polymorphism is not associated with male infertility.